Career Profile

Unraveling a path of Applied Scientific Research…

Research work at IDS-Lab. I worked on image restoration/reconstruction techniques by sparse regularization techniques such as Compressed Sensing, Dantzig Selector and BPDN. I focused specifically at incorporating spatial correlations by experimental covariance matrices. Next to the master student, Thomas Peet Moraga, we worked together on theoretical formulation and experimental analysis of Optimal Well Placement related to the best way of distributing measurements. This work was part of a research project focused on the optimization of sensing/locating resources in areas of mining and drilling. This work aims at obtaining the optimal positions to effect a preset amount of available measurements. Geostatistical and theoretical information tools have contextualized. These works are part of the FONDECYT 1140840 project.

Research work in SCIAN-Lab, Leo-Lab, and BNI, at Medicine Fac., U. Chile. Scian-Lab: Work in SOFI microscopy and the characterization of Qdots by spectrum analysis of blinking curves, Leo-Lab: I developed a mathematical model to describe the collective migration and guidance processes for Kupffer vesicle formation in Zebra Fish. These works are part of FONDECYT 1120558 project.

Teaching: Professor at Master course: Image and biosignal processing II (Medicine Fac., U. Chile). (Co)-localization Theory: (Super)-Resolution and Overlapping/Colocalization. Super-resolution optical imaging fluctuation (Hand-on Activity).

Coding on IDL, Matlab, C++, Objective C, Swift, Python, .Net, HPC Matlab PCT, CUDA, MPI

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Experiences

Applied Scientific Postdoctoral Research

2018 - Present
Advanced Laboratory for Geostatistical Supercomputing, ALGES-AMTC Universidad de Chile. Santiago, Chile

Applied scientific research related with topics of machine learning classification and mathematical modelling of multidimensional data, hyper-spectral images, data fusion and super-resolution.

  • Characterization and classification of hyper-spectral data
  • Mineralogical data
  • Microscopic and biomedical sources

Principal Hardware and Software Engineer

2017 - 2020
Micromundo Chile Spa (https://micromundo.app/), Santiago, Chile

Develop new educational methodologies based on school scientific research.

  • Integrate low cost microscopy, image processing and virtual microscopy for the generation of didactic educational content aimed at basic and middle school students.
  • Make available to teachers and students the tools and knowledge in virtual microscopy that allow them to generate advanced scientific research.

Medical Informatics / Informatics Pathology Teacher

2017 - Present
Medical Technology School, Campus Providencia, Universidad San Sebastian. Santiago.

Development of activities related to Microscopy, Optics and Image Processing. Exhibitions related to topics on physics, optics, image capture and applied mathematical tools for digital processing of images applied in Medical Informatics / Informatics Pathology.

  • Development, implementation and execution of practicals aimed at providing knowledge and support on the use of scientific software for image processing and mathematical analysis
  • FIJI and ImageJ

Freelancer in Software Development and Support

2017 - 2019
Private Companies

Electronic and Computer Support, Fieldwork and Remote Assistance.

  • Software Implementation and Optimization.
  • Asp.Net Web App for manage of Photography, GIF and Video and Sharing on Social networks

Hardware and Software Engineer

2011 - 2016
Biomedical Neuroscience Institute (BNI), University of Chile. Santiago

Software Development for Scientific Computing on Microscopy with Biomedical Applications. Project ICM (P04-068-F, P09-015-F), Image Processing Software Development for Scientific Computing on Microscopy with Biomedical Applications.

  • Development and support for modeling and optimization of algorithms and Software for developmental biology phenomenon and applied sciences. Development of Super-resolution microscopy techniques.
  • Algorithms for skeletonization in models of biological structures based on 3D cloud points approach and Octree graphs extraction and reduction.
  • Collaborative work with the III Physics Institute at the Georg-August-Universität Göttingen (Germany), in a novel super-resolution microscopy technique based on statistical analysis for spatio-temporal data in large microscopy images. Development and extension of the SOFI (spatial-temporal fluctuation imaging) technique for a first implementation in microscopy facilities at the University of Chile.
  • Optimization and parallelization of the SOFI calculation using a cluster with MATLAB Parallel Computing Toolbox and the CUDA concurrent programming language

Research assistant, Support Electronic Engineer

2010 - 2011
Nucleo Milenio NEMO, School of Medicine & School of Physical and Mathematical Sciences. University of Chile

Project NEMO (P07-048-F). Development and support for modeling, parallelization and optimization of algorithms and Software of NEMO lab for developmental biology phenomenon and applied sciences.

  • Development of methodology for parameters extraction for Skeleton-like structures in biological images of microscopy
  • Optimization and correction of SCIAN-Soft software and graphic models for visual parameters representation

Project Coordinator

2011 - 2011
Heidelberg Center para América Latina

Project Medical Informatics Santiago-Heidelberg (http://www.heidelbergcenter.cl/medicalinformatics/en/). Support Plan and Development of Excellence center of Medical Informatics in Latin-American between the Universidad de Chile and the Heidelberg Center of University of Heidelberg.

  • Participate and support the First Summer School “Health Informatics”: Telemedicine and Health Information Systems (2010) and the First version of Diplomado: “Health Information Systems: Social and technical requirements for successful design and deployment” (2011).
  • Presently supporting the formulation and presentation of Master in Medical Informatics in the Universidad de Chile

Researcher- Software Engineer

2009 - 2011
Faculty of Physical Sciences and Mathematics, Universidad de Concepción.

Implementation of algorithms and mathematical modeling of collision detection, calculation of contact and collision between objects modeled by geometric meshs, soft tissue deformation and haptic force feedback. Implementation of interaction of two haptic devices in dual configuration interface developed for Windows Forms. The work has been synthesized in degree thesis “Collision Detection and Haptic feedback in virtual simulator for surgical training”.

  • Development Platform for Micro and Nano Optics Handling interactive in Real-time using optical tweezers and spatial light modulator (SLM).
  • Implementation, review and correction of algorithms for physical and haptic (force feedback) interactions. Implementation of texture-based haptic interaction. Developed in MFC and Flash platform.
  • MCGA visualization interface development for a risk prevention software .Build prototype of graphic module for generator for alerts in real-time monitoring of geopositioning. Developed in Java for project requirements.
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Projects

Some Projects.

Micromundo - Fondo de Capital Semilla para el Desarrollo Ágil de Emprendimientos TIC desde Chile para America Latina y el Mundo” Programa:Corfo Folio/N°: 14SSAF-270.
Fast SLMIC - Portable and low-cost 3D printed microscopy based on adaptive structured lighting, a new high-resolution alternative in diagnostics and education.
NEMO - Quantitative in vivo imaging techniques with high temporal and spatial resolution for molecular neuroscience, development, morphogenesis, neuropathology.
FONDECYT 1120579 - Fast Computational Schemes for the Analysis of Morpho-Topological Data from High Throughput Microscopy.
FeelIT - An interactive platform for the visually impaired with haptic-based virtual relief representation
Holo Optical Twezzers - Interactive platform for micro and nano optics handling in Real-time
Project FONDEF (D06I1057) - Arthroscopic Training System Based On Interactive Visualization and Haptic Devices
MCGA visualization interface - MCGA visualization interface for a risk prevention software, graphic module for alerts generator in real-time monitoring of geopositioning.
Platform VICE - Project FONDEF (TE06I1014), Development Platform VICE Based Visualization Technology and Haptic Devices (VICE).
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Publications

Last Scientific Publications.

  • A Robust Stochastic Approach to Mineral Hyperspectral Analysis for Geometallurgy
  • Alvaro F. Egaña, Felipe A. Santibáñez-Leal, Christian Vidal, Gonzalo Díaz, Sergio Liberman, Alejandro Ehrenfeld
    Special Issue: Advanced Spectral Techniques for Mineralogical and Elemental Analysis in Mining and Mineral Processing. Minerals 2020, 10(12), 1139
  • Multi Pixel Stochastic Approach to Mineral Samples Spectral Analysis for Geometallurgical Modeling
  • Cristian F. Jara, Alejandro Ehrenfeld, Álvaro F. Egaña, Christian Vidal, Felipe A. Santibáñez-Leal
    Procemin Geomet 2020, Chile
  • Ore-Waste Discrimination with Adaptive Sampling Strategy
  • Felipe A. Santibáñez-Leal, Julián M. Ortiz & Jorge F. Silva
    Natural Resources Research volume 29, pages 3079–3102 (2020)
  • Sampling strategies for uncertainty reduction in categorical random fields: Formulation, mathematical analysis and application to multiple-point simulations
  • Felipe Santibáñez-Leal, Jorge F. Silva & Julián M. Ortiz
    Mathematical Geosciences volume 51, pages 579–624 (2019)
  • Geological Facies Recovery Based on Weighted l1-Regularization
  • Hernan Calderon, Felipe Santibañez, Jorge F. Silva, Julián M. Ortiz & Alvaro Egaña
    Mathematical Geosciences volume 52, pages 593–617 (2020)
  • Channelized facies recovery based on weighted compressed sensing
  • Hernán Calderón, Felipe Santibañez, Jorge F. Silva, Julián Ortiz, Álvaro Egaña
    2016 IEEE Sensor Array and Multichannel Signal Processing Workshop (SAM), Rio de Janerio, pp. 1-5 (2016)
  • Computational methods for analysis of dynamic events in cell migration
  • V Castañeda, M Cerda, F Santibáñez, J Jara, E Pulgar, K Palma, C G Lemus, M Osorio-Reich, M L Concha, S Hartel
    Curr Mol Med. 14(2): pages 291-307 (2014)
  • SOFI of GABAB neurotransmitter receptors in hippocampal neurons elucidates intracellular receptor trafficking and assembly
  • Anja Huss, Omar Ramírez, Felipe Santibáñez, Andrés Couve, Steffen Härtel, Jörg Enderlein
    Proc. SPIE 8590, Single Molecule Spectroscopy and Superresolution Imaging VI, 85900N (2013)
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    Skills & Proficiency

    Scientific Programming

    Python

    C/C#

    IDL

    Matlab & Simulink

    HTML5 & CSS

    Assembler

    Verilog & Abel